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Loading Cart...First Randomized, Double-blind, Placebo Controlled Study To Show Telomeres Getting Longer In Humans
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period.
The study was conducted on 97 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period, as compared to the placebo group (530 ± 180 bp; p = 0.005), whereas subjects in the placebo group significantly lost TL (290 ± 100 bp; p = 0.01). The high dose of TA-65 (1000 U) showed a trend of improvements in TL compared with that of the placebo group; however, the improvements did not reach statistical significance. TL changes in the low-dose group were similar for both median and 20th percentile TLs. The findings suggest that TA-65 can lengthen telomeres in a statistically and possibly clinically significant manner.
Study Summary
- Study participants: 97 men and women (53-87 years old)
- Study length: 12 months
- First study to show statistically significant (p<0.005) lengthening of telomeres in humans:
As expected, the placebo group showed a decrease in telomere length
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Placebo Group |
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| Median telomere length | 290 ± 100 bp |
| 20th percentile telomere length | 170 ± 50 bp |
While the group taking one capsule of TA-65® (250 Units) per day showed an increase in telomere length
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TA-65® Group |
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| Median telomere length | 533 ± 180 bp |
| 20th percentile telomere length | 270 ± 90 bp |
- Published in Rejuvenation Research, a PubMed-indexed and peer-reviewed journal — [PMID: 26950204]
