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Telomere testing: your cellular health stethoscope

Your patients may ask: Why should I measure my telomeres? Once you tell them telomere length has been associated with a slew of adult onset maladies, they take note.

TA Sciences

We’ve come a long way since the 2009 Nobel Prize was awarded to the scientists that demonstrated how telomeres and the telomerase enzyme protect our chromosomes.

After years of monitoring diagnostic tests, our research team has determined which telomere tests provide the same level of efficacy as other go-to biomarker tests.

We suggest asking your patients: “Do you know the difference between your chronological age and your biological age?” This usually has them riveted with curiosity, and requesting testing.

Their chronological age – the number of years they’ve been on earth – may be lower than their biological age, which is influenced by diet, exercise, lifestyle, sleep and stress (all factors that affect telomere length). Telomeres dictate how quickly each cell in your body ages. And now that we know they can be lengthened, it’s more important than ever to track your telomere length.

Once you’ve determined a patient’s biological baseline, he or she may want to see how it compares with that of his or her chronological peers – another popular option. After providing a full vial of whole blood, patients can expect to see results in 2 -3 weeks.

Here are the tests that have earned our research team’s 5-star reviews.

Please note telomere testing should be repeated annually. Additionally, based on unique methodologies from each company, whichever test you chose for your baseline, the follow-up needs to be from the same company.

Life Length

Life Length
www.lifelength.com

Methodology: HT Q-FISH (High-Throughput Quantitative Fluorescence In situ Hybridization) combines labeling of telomeres in interphase nuclei with a fluorescent nucleotide probe against telomeric repeats, with automated HT microscopy in 96-well plates.

Used in 35 countries, this is the only test that measures median and critically short telomere lengths. Life Length’s TAT test measures over 100,000 individual telomeres, chromosome-by-chromosome in tens of thousands of cells, and offers detailed analysis of:

  • distribution of normal and critically short telomeres to determine biological age
  • the rate of telomere attrition on a longitudinal basis
  • video guides to help you analyze test results and explain them to patients

Repeat Diagnostics

Repeat Diagnostics
www.repeatdx.com

Methodology: FlowFISH (fluorescent in-situ hybridization) combines peptide nucleic acid probes with fluorescence measurements to quantify multiple repetitive parameters in the genomic DNA inside thousands of cells.

Using flow cytometry Repeat Dx assesses fluorescent signals from telomeres on a single cell basis, then reports telomere lengths in these cell types:

  • lymphocytes
  • granulocytes
  • B-cells
  • naïve cells
  • memory T-cells
  • NK cells

SpectraCell Laboratories

SpectraCell Laboratories
www.spectracell.com

Methodology: PCR (polymerase chain reaction) technology amplifies and copies DNA until there is enough of it to analyze.

SpectraCell’s telomere percentile score is calculated based on average telomere length in peripheral whole blood cells, then compared to telomere lengths from a same age population sample. It calculates cellular attrition by analyzing the rate at which changes in average telomere length occur over time causing cells to either die or be replaced by monitoring:

  • cell lysis: the breakdown of cells to avoid degradation of sensitive proteins and DNA
  • DNA extraction: to track telomere sequence repetition amplification

UCLA Immunology biomarker panel

UCLA Immunology biomarker panel
Contact TA Sciences for this exclusive test

Contact T.A. Sciences about this exclusive, additional non-telomere test to measure the biomarkers of immunology. Although it’s not a telomere test, this immunophenotyping assay complements any of the telomere tests listed above.

Methodology: Flow Cytometry (using laser wavelengths to determine cell properties)

Using UCLA’s custom Flow Cytometry our licensees deliver baseline testing to detect these crucial immune system markers:

  • CD3+ (T-Lymphocytes)
  • CD4+ (T-Helper/Inducer)
  • CD8+ (T-Suppressor/Cytotoxic)
  • CD19+ (B-Lymphocytes)
  • CD56+/16+ (NK cells)
  • CD3+/CD8+/CD28-
  • CD3+/CD8+/CD95-
  • CD8+/CD28-
  • CD8+/CD95- (Naïve Cytotoxic T Cells)

This panel allows follow-up within 90-180 days to track immune function fluctuations. TA Sciences offers exclusive testing kits to physician licensees or healthcare provider partners.