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“The shorter your telomeres, the short your lifespan.”

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Could the secrets to anti-aging be at the tips of our chromosomes?
By Mandy Kendrick

Peter Pan stayed forever young in Neverland. In real life, some scientists are looking at telomeres, or regions of repetitive DNA at the ends of our chromosomes, to try to arrive at something like a real version of this story.

Telomeres consist of up to 3,300 repeats of the DNA sequence TTAGGG. They protect chromosome ends from being mistaken for broken pieces of DNA that would otherwise be fixed by cellular repair machinery. But every time our cells divide, the telomeres shrink. When they get short enough, our cells no longer divide and our body stops making those cells. Over time, this leads to aging and death. New York-based T.A. Sciences claims to be the only company in the world manufacturing a supplement in a pill form that has been lab tested and shown to stop telomeres from shortening, in hopes of halting the aging process. The product, TA-65, comes from extracts of the Chinese herb astragalus, which has been used for medicinal purposes for more than 1,000 years, says Noel Patton, chief executive officer of the company.

TA-65 is produced at very low levels in the astragalus plant, but the company purifies and concentrates the substance, which is thought to “turn on” the enzyme telomerase (hTERT) that acts to maintain or lengthen telomeres. hTERT is usually “off” in adult cells, except in immune, egg and sperm cells, and in malignant cancer-forming cells.

The TA-65 pill requires no approval from the U.S. Food and Drug Administration because it is marketed as a supplement and not a drug. Therefore, T.A. Sciences cannot make claims about the drug’s efficacy at curing disease. But Patton and Calvin Harley, the chief scientific officer at Geron—the company that discovered TA-65—go on to note that researchers have found a correlation between telomere length and susceptibility to certain aging-related diseases.

T.A. Sciences did five years of testing on TA-65, beginning in 2002. Results from an anti-aging trial can be found at the company’s Web site. Patton says he has been taking the supplement for two years and that everyone at T.A. Sciences over the age of 40 takes the product.

William Andrews has worked on telomere biology for the past 15 years. He is the chief executive officer of Sierra Sciences, LLC, a rival company that is screening for chemicals to activate telomerase, but also a T.A. Sciences client for the past two-and-a-half years. He thinks that “taking a telomerase inducer is safer than driving my car to work” but acknowledges that there are some unknown risks with taking the product. For example, telomerase is the same enzyme that allows cancer cells to stop aging or to become immortal, so there is a chance that TA-65 could keep alive cancer cells that would otherwise die, notes Andrews.

However, telomerase activation should keep all telomeres longer in the first place, and that actually reduces the chances of cells becoming cancerous, Andrews notes. He also says that the enzyme should keep immune cells, which can fight off most cancerous cells, alive longer.

Another problem facing telomere science is that no suitable model organism is available for testing. Animals do not age through telomere shortening in the same way that humans do, Harley notes, adding that “not even mice or monkeys have the same telomere aging system. The best system to ultimately test is going to be the human.”

The potential benefits of the supplement seem to outweigh the risk for patients like Andrews. “People such as myself who elect to take TA-65 and look forward to taking even stronger telomerase inducers in the future must act totally on gut feelings,” Andrews notes.

For those who are less adventurous, other researchers have identified lifestyle changes that can help optimize telomerase activity, without the $14,000-per-year price tag of the TA-65 treatment.

“The quest for the test tube of youth

First they beat the squares, the war and the patriarchy. Now the baby-boom generation wants to outwit Father Time. Fears of mortality and elder-care burdens are giving science a senior moment as labs investigate how to sustain healthy vigour far into old age. But is cheating frailty and death more than a vain dream?”

“Telomere biologist Bill Andrews of Sierra Sciences is taking a telomerase-boosting supplement called TA-65. “I believe it’s safer than driving my car to work,” he says. Since he started taking it a year and a half ago, Andrews says he has moved from the back of the pack to the front in 100-mile runs known as ultramarathons.”

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The Pivotal 2005 Anti-Aging Trial was a 24-week double-blind, placebo-controlled study involving 36 male subjects between 60 and 85 years of age. The study notes that there has been significant research on the role of cellular aging and telomere attrition in several types of skin cells, including keratinocytes, fibroblasts, microvascular endothelial cells and melanocytes. The results of this study suggest that TA-65 improves the structure and/or function of skin in older people.

According to PRNewswire, the study results also showed that subjects experienced improvement in immune system function, vision, sexual function, energy levels and overall sense of well-being.

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